ٹرامادول: گردانَن مَنٛز فَرَق

'''ٹرامادول''' یس '''الٹرام''' برانڈ ناوس تحت کٕنٛنہٕ چھُ یوان، چھُ اکھاَکھ اوپییوڈ دگہٕ ہُنٛد دوا یُس ہلکہ پیٚٹھٕ معتدل شدید واجنہٕ دگہ علاج کرنہٕ خٲطرٕ استعمالاِستِمال چھُ گژھان۔<ref name="generics">{{ویب حَوالہٕ|title=Tramadol|url=https://www.drugs.com/international/tramadol.html|website=Drugs.com|access-date=22 December 2018|language=en|archive-date=23 July 2018|archive-url=https://web.archive.org/web/20180723182517/https://www.drugs.com/international/tramadol.html|url-status=live}}</ref><ref name="AHFS2014">{{ویب حَوالہٕ|title=Tramadol Hydrochloride|url=https://www.drugs.com/monograph/tramadol-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|access-date=Dec 1, 2014|archive-date=12 November 2020|archive-url=https://web.archive.org/web/20201112015421/https://www.drugs.com/monograph/tramadol-hydrochloride.html|url-status=live}}</ref> یہیہِ چھ عام طور پٲٹھۍپٲٹھؠ دگٕچ باقی دواہن ہنٛدس مقابلس منٛزمَنٛز کم ترجیٖح دنہٕ یوان۔<ref name="TI2021">{{ویب حَوالہٕ|title=[131] Tramadol: Where do we go from here?|url=https://www.ti.ubc.ca/2021/07/14/131-tramadol/|access-date=14 September 2021|archive-date=16 July 2021|archive-url=https://web.archive.org/web/20210716014831/https://www.ti.ubc.ca/2021/07/14/131-tramadol/|url-status=live}}</ref> ییلہ فوری طور جٲری کرنہٕ ینہٕ واجنیٚن فارمولیشنن منٛزمَنٛز واتہٕ ذٔریع ننہٕ چھ یوان، تیٚلہ چھ دگٕ سۭتۍسٟتؠ راحتٕچ شروعات عام طور أکس گٲنٛٹہٕ اندر شروعشۆروٗع گژھان۔<ref name="AHFS2014" /> یہیہِ چھ انجیکشن کہ ذریع تہٕ دستیاب۔<ref name="BNF74">{{کِتاب حَوالہٕ|title=British national formulary : BNF 74|date=2017|publisher=British Medical Association|isbn=978-0857112989|pages=447–448|edition=74}}</ref> یہٕ چھ [[پیراسیٹامول]] (acetaminophen) سۭتۍسٟتؠ ملتھ کننہٕ یوان یا زیٹھ کٲم کرن وألن فارمولیشنن ہنٛد پأٹھۍ۔پأٹھؠ۔<ref name="AHFS2014" /><ref name="BNF74" />

یتھیَتھ کٔنۍکٔنؠ ز اوپییوڈٕچ خصوصیت چھ، عام ضمنی اثرات منٛزمَنٛز چھ قبض، کھجلی تہٕ متلی شٲمل۔<ref name="AHFS2014">{{ویب حَوالہٕ|title=Tramadol Hydrochloride|url=https://www.drugs.com/monograph/tramadol-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|access-date=Dec 1, 2014|archive-date=12 November 2020|archive-url=https://web.archive.org/web/20201112015421/https://www.drugs.com/monograph/tramadol-hydrochloride.html|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/tramadol-hydrochloride.html "Tramadol Hydrochloride"]. The American Society of Health-System Pharmacists. [https://web.archive.org/web/20201112015421/https://www.drugs.com/monograph/tramadol-hydrochloride.html Archived] from the original on 12 November 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">Dec 1,</span> 2014</span>.</cite><span data-ve-ignore="true"> </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true"><code class="cs1-code"><nowiki>{{</nowiki>[[فرما:ویب حَوالہٕ|cite web]]<nowiki>}}</nowiki></code>: </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true">More than one of <code class="cs1-code">&#x7C;archivedate=</code> and <code class="cs1-code">&#x7C;archive-date=</code> specified ([[مدد: CS1 غلطیاں|help]])</span><span data-ve-ignore="true">; </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true">More than one of <code class="cs1-code">&#x7C;archiveurl=</code> and <code class="cs1-code">&#x7C;archive-url=</code> specified ([[مدد: CS1 غلطیاں|help]])</span>

[[Category:CS1 errors: redundant parameter|ο]]</ref> سنگین مضر اثراتس منٛزمَنٛز ہیکن دورٕ، سیرٹونن سنڈروم خطرٕ بڑن، چوکسی منٛزمَنٛز کمی، تہٕ نشہ نشہ نشہ نشہ گژھن واجنہ چیز شٲمل ٲستھ۔<ref name="AHFS2014" /> یمن گردٕ۔ یا جگرک مسلہٕ چھ تمن منٛزمَنٛز چھ خوراک تبدیل کرنٕچ تجویز یوان دنہٕ۔<ref name="AHFS2014" /> یہیہِ چھنہٕ تمن لوکن منٛزمَنٛز تجویز یوان کرنہٕ یمن منٛزمَنٛز خودکشی ہنٛد خطرٕ چھ آسان یا تمن منٛزمَنٛز یم حاملہ چھ آسان۔<ref name="AHFS2014" /><ref name="BNF74">{{کِتاب حَوالہٕ|title=British national formulary : BNF 74|date=2017|publisher=British Medical Association|isbn=978-0857112989|pages=447–448|edition=74}}<cite class="citation book cs1" data-ve-ignore="true">''British national formulary : BNF 74'' (74&nbsp;ed.). British Medical Association.Association۔ 2017.2017۔ pp.&nbsp;447–448. [[بَین الاقوٲمی معیار کِتاب نَمبَر|ISBN]]&nbsp;[[خصوصی: کتابی ذرائع/978-0857112989|<bdi>978-0857112989</bdi>]].</cite></ref> اگرچہ دودھ پلاو۔ وٲل زنانن منٛزمَنٛز چھنہٕ یہیہِ تجویز یوان کرنہٕ، مگر یم وٲحد ڈوز چھ نوان تمن پزٕ نہٕ عام طور پٲنٹھ دودھ پلاون بند کرن۔<ref>{{ویب حَوالہٕ|title=Tramadol Pregnancy and Breastfeeding Warnings|url=https://www.drugs.com/pregnancy/tramadol.html|website=Drugs.com|access-date=5 September 2016|archive-date=13 April 2020|archive-url=https://web.archive.org/web/20200413050449/https://www.drugs.com/pregnancy/tramadol.html|url-status=live}}</ref> ٹرامادول چھ جگرس منٛزمَنٛز O-desmethyltramadol (desmetramadol) منٛزمَنٛز تبدیل یوان کرنہٕ یس اکھاَکھ اوپییوڈ چھ یس μ-opioid رسیپٹرس سۭتۍسٟتؠ مضبوط طور پٲنٹھ جڑتھ چھ آسان۔<ref name="AHFS2014" /><ref name="Raf2012">{{Cite journal|vauthors=Raffa RB, Buschmann H, Christoph T, Eichenbaum G, Englberger W, Flores CM, Hertrampf T, Kögel B, Schiene K, Straßburger W, Terlinden R, Tzschentke TM|title=Mechanistic and functional differentiation of tapentadol and tramadol|journal=Expert Opin Pharmacother|volume=13|issue=10|pages=1437–49|year=2012|pmid=22698264|doi=10.1517/14656566.2012.696097|url=}}</ref> ٹرامادول چھ اکھاَکھ سیرٹونن-نورپینفنائن ریپٹیک انفیکٹر (SNRI) تہٕ۔<ref name="AHFS2014" /><ref name="PHR2009">{{Cite journal|vauthors=Leppert W|title=Tramadol as an analgesic for mild to moderate cancer pain.|journal=Pharmacological Reports|date=November–December 2009|volume=61|issue=6|pages=978–92|pmid=20081232|url=http://www.if-pan.krakow.pl/pjp/pdf/2009/6_978.pdf|doi=10.1016/s1734-1140(09)70159-8|access-date=6 August 2020|archive-date=17 October 2016|archive-url=https://web.archive.org/web/20161017220350/http://www.if-pan.krakow.pl/pjp/pdf/2009/6_978.pdf|url-status=live}}</ref>

ٹرامادول اوس 1963 منٛزمَنٛز پیٹنٹ کرنہٕ آمت تہٕ مغربی جرمن دوا ساز کمپنی گرونینتھال جی ایم بی ایچ کہ ذریع 1977 منٛزمَنٛز "ٹرامل" ناوٕ سٟتؠ اوس شروعشۆروٗع آمت کرنہٕ۔<ref name="PHR2009" /><ref name="Fis2006">{{کِتاب حَوالہٕ|last=Fischer|first=Jnos|last2=Ganellin|first2=C. Robin|title=Analogue-based Drug Discovery|date=2006|publisher=John Wiley & Sons|isbn=9783527607495|page=528|url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA528|language=en|access-date=6 August 2020|archive-date=14 October 2022|archive-url=https://web.archive.org/web/20221014082428/https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA528|url-status=live}}</ref> 1990 کس دہائی کِس وسطس منٛز،مَنٛز، یہٕ آو برطانیہس تہٕ امریکہس منٛزمَنٛز منظور کرنہٕ۔<ref name="PHR2009">{{Cite journal|vauthors=Leppert W|title=Tramadol as an analgesic for mild to moderate cancer pain.|journal=Pharmacological Reports|date=November–December 2009|volume=61|issue=6|pages=978–92|pmid=20081232|url=http://www.if-pan.krakow.pl/pjp/pdf/2009/6_978.pdf|doi=10.1016/s1734-1140(09)70159-8|access-date=6 August 2020|archive-date=17 October 2016|archive-url=https://web.archive.org/web/20161017220350/http://www.if-pan.krakow.pl/pjp/pdf/2009/6_978.pdf|url-status=live}}<cite class="citation journal cs1" data-ve-ignore="true" id="CITEREFLeppert2009">Leppert W (November–December 2009). [http://www.if-pan.krakow.pl/pjp/pdf/2009/6_978.pdf "Tramadol as an analgesic for mild to moderate cancer pain"] <span class="cs1-format">(PDF)</span>. ''Pharmacological Reports''. '''61''' (6): 978–92. [[ڈون (شناخت)|doi]]:[https://doi.org/10.1016%2Fs1734-1140%2809%2970159-8 10.1016/s1734-1140(09)70159-8]. [[پی ایم آئی ڈی (شناخت)|PMID]]&nbsp;[https://pubmed.ncbi.nlm.nih.gov/20081232 20081232]. [https://web.archive.org/web/20161017220350/http://www.if-pan.krakow.pl/pjp/pdf/2009/6_978.pdf Archived] <span class="cs1-format">(PDF)</span> from the original on 17 October 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">6 August</span> 2020</span>.</cite><span data-ve-ignore="true"> </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true"><code class="cs1-code"><nowiki>{{</nowiki>[[فرما:Cite journal|cite journal]]<nowiki>}}</nowiki></code>: </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true">More than one of <code class="cs1-code">&#x7C;accessdate=</code> and <code class="cs1-code">&#x7C;access-date=</code> specified ([[مدد: CS1 غلطیاں|help]])</span><span data-ve-ignore="true">; </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true">More than one of <code class="cs1-code">&#x7C;archivedate=</code> and <code class="cs1-code">&#x7C;archive-date=</code> specified ([[مدد: CS1 غلطیاں|help]])</span><span data-ve-ignore="true">; </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true">More than one of <code class="cs1-code">&#x7C;archiveurl=</code> and <code class="cs1-code">&#x7C;archive-url=</code> specified ([[مدد: CS1 غلطیاں|help]])</span>

[[Category:CS1 errors: redundant parameter|ο]]</ref> یہیہِ چھُ عام دوا کِس طورس پیٚٹھ دستیاب تہٕ چھ پوٗرٕ دنیاہس منٛزمَنٛز واریاہن برانڈن ہٕنٛدس ناوس تحت مارکیٹنگ کرنہٕ یوان۔<ref name="AHFS2014">{{ویب حَوالہٕ|title=Tramadol Hydrochloride|url=https://www.drugs.com/monograph/tramadol-hydrochloride.html|publisher=The American Society of Health-System Pharmacists|access-date=Dec 1, 2014|archive-date=12 November 2020|archive-url=https://web.archive.org/web/20201112015421/https://www.drugs.com/monograph/tramadol-hydrochloride.html|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.drugs.com/monograph/tramadol-hydrochloride.html "Tramadol Hydrochloride"]. The American Society of Health-System Pharmacists. [https://web.archive.org/web/20201112015421/https://www.drugs.com/monograph/tramadol-hydrochloride.html Archived] from the original on 12 November 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">Dec 1,</span> 2014</span>.</cite><span data-ve-ignore="true"> </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true"><code class="cs1-code"><nowiki>{{</nowiki>[[فرما:ویب حَوالہٕ|cite web]]<nowiki>}}</nowiki></code>: </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true">More than one of <code class="cs1-code">&#x7C;archivedate=</code> and <code class="cs1-code">&#x7C;archive-date=</code> specified ([[مدد: CS1 غلطیاں|help]])</span><span data-ve-ignore="true">; </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true">More than one of <code class="cs1-code">&#x7C;archiveurl=</code> and <code class="cs1-code">&#x7C;archive-url=</code> specified ([[مدد: CS1 غلطیاں|help]])</span>

[[Category:CS1 errors: redundant parameter|ο]]</ref> ریاستہائے متحدہس منٛزمَنٛز چھ 2018 ہس تام تھوک قیمت 0.05 امریکی ڈالر فی ڈوز کھوتہٕ کم۔<ref name="ref">{{ویب حَوالہٕ|title=NADAC as of 2018-12-19|url=https://data.medicaid.gov/Drug-Pricing-and-Payment/NADAC-as-of-2018-12-19/g7bs-ahj4|website=Centers for Medicare and Medicaid Services|access-date=22 December 2018|archive-date=19 December 2018|archive-url=https://web.archive.org/web/20181219230344/https://data.medicaid.gov/Drug-Pricing-and-Payment/NADAC-as-of-2018-12-19/g7bs-ahj4|url-status=deviated}}</ref> کینیڈاہس منٛزمَنٛز چھ 2021 ہس تام فی ڈوز تقریبا 1.20 سی اے ڈی لاگت یوان۔<ref name="TI2021">{{ویب حَوالہٕ|title=[131] Tramadol: Where do we go from here?|url=https://www.ti.ubc.ca/2021/07/14/131-tramadol/|access-date=14 September 2021|archive-date=16 July 2021|archive-url=https://web.archive.org/web/20210716014831/https://www.ti.ubc.ca/2021/07/14/131-tramadol/|url-status=live}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.ti.ubc.ca/2021/07/14/131-tramadol/ "&#x5B;131&#x5D; Tramadol: Where do we go from here?"]. [https://web.archive.org/web/20210716014831/https://www.ti.ubc.ca/2021/07/14/131-tramadol/ Archived] from the original on 16 July 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">14 September</span> 2021</span>.</cite><span data-ve-ignore="true"> </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true"><code class="cs1-code"><nowiki>{{</nowiki>[[فرما:ویب حَوالہٕ|cite web]]<nowiki>}}</nowiki></code>: </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true">More than one of <code class="cs1-code">&#x7C;archivedate=</code> and <code class="cs1-code">&#x7C;archive-date=</code> specified ([[مدد: CS1 غلطیاں|help]])</span><span data-ve-ignore="true">; </span><span class="cs1-visible-error citation-comment" data-ve-ignore="true">More than one of <code class="cs1-code">&#x7C;archiveurl=</code> and <code class="cs1-code">&#x7C;archive-url=</code> specified ([[مدد: CS1 غلطیاں|help]])</span>

</ref> 2017 منٛز،مَنٛز، اوس یہیہِ ریاستہائے متحدس منٛزمَنٛز 32 ہم سارویسارِوٕے کھوتہٕ زیادٕزیٛادٕ عام طور پٲنٹھ تجویز کرنہٕ آمت دوا، یتھیَتھ منٛزمَنٛز 21 ملین کھوتہٕ زیادٕزیٛادٕ نسخہٕ چھ۔<ref name="ref1">{{ویب حَوالہٕ|title=The Top 300 of 2020|url=https://clincalc.com/DrugStats/Top300Drugs.aspx|website=ClinCalc|access-date=11 April 2020|archive-date=18 March 2020|archive-url=https://web.archive.org/web/20200318234059/https://clincalc.com/DrugStats/Top300Drugs.aspx|url-status=live}}</ref><ref name="ref2">{{ویب حَوالہٕ|title=Tramadol Hydrochloride - Drug Usage Statistics|website=ClinCalc|date=23 December 2019|url=https://clincalc.com/DrugStats/Drugs/TramadolHydrochloride|access-date=11 April 2020|archive-date=11 April 2020|archive-url=https://web.archive.org/web/20200411201148/https://clincalc.com/DrugStats/Drugs/TramadolHydrochloride|url-status=deviated}}</ref>